Esomizole

Esomizole 40 MG

Esomeprazole 40 mg Tablets (With Sodium Bicarbonate as Buffer) Tablets

Medoxy Healthcare Private Limited

N18-1008, 18 JAYPEE AMAN , SEC 151,
Noida, Police Station 201301, Noida,
Gautam Buddha Nagar 201301, Uttar Pradesh,India

Esomizole D

Esomeprazole EC 40 mg with Domperidone 30 mg SR Capsules

Indication

GERD
NAB (Nocturnal Acid Breakthrough)
Diabetic Gastroparesis
Functional Dyspepsia
Gastritis

Mechanism of Action

Esomeprazole is the S-enantiomer of omeprazole, specifically act on proton pump inhibitor, suppressing gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell and blocking the final step in acid production, resulting in reduced gastric acidity.

Domperidone has strong affinities for the D2 and D3 dopamine receptors,found in the chemoreceptor trigger zone, located just outside the blood brain barrier. It facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure.

Itopride inhibits transient LES relaxations (TLESRs)without significantly affecting oesophageal peristaltic function or LES pressure.